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JPY
Abstract
Meta-analysis emerged in 1976 and the first application in medicine was published in 1985. This article reviews the evolution of meta-analysis and future challenges. Three events having advanced meta-analysis were first discussed. Those are Cochrane collaboration, evidence-based medicine, and comparative effectiveness research. These events contributed to move forward the application of meta-analysis. Network meta-analysis may be a breakthrough to allow for indirect comparisons that are necessary to conduct the comparative effectiveness research. Methodological advances and educational tools were also briefly reviewed. Four controversies related to the results of meta-analysis were demonstrated. Finally, the author recalled careful evaluation using checklists since similar meta-analyses have been published.
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