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薬理と治療
Abstract
Globin digest(GD), an oligopeptide mixture derived from edible globin proteins, improved hyperlipidemia and hyperglycemia in human and other mammals, and is used as Food for Specified Health Use(FOSHU)in Japan and Health Food in China, but the effect of GD on the blood pressure was unknown. In the present study, the effect of GD on the blood pressure in spontaneously hypertensive rats(SHR╱Izm: SHR)was examined. At first, GD was administered orally once to SHR(15-18 weeks old). GD(500 mg and 1000 mg╱kg body weight)suppressed the systolic blood pressure in SHR after a single administration. Next, SHR(7weeks old)were fed a diet containing GD(0.5 wt%), magnesium(Mg)hydroxide(1.95 wt%, as Mg 0.81 wt%)or the combination of Mg hydroxide with GD for 12 weeks. The elevation of the systolic blood pressure in SHR was suppressed by GD or Mg hydroxide and most suppressed by the combination of Mg hydroxide with GD. GD inhibited the activity of angiotensin-converting enzyme in vitro. These findings indicate that GD has the antihypertensive effect and more effective by use with Mg in SHR.
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