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薬理と治療
Abstract
Objectives We evaluate efficacy of a dietary supplement containing bovine alpha S1-casein tryptic hydrolysate, Hemerocallis flower extract, Arginin, and Ornithine on sleep disorders among Japanese adults. Methods Ten subjects with sleep disorders were provided dietary supplement for two weeks. Each subject ingested every night during the treatment period. We evaluated sleep quality by using PSQI(Pittsburgh sleep quality index), OSA-MA(OSA sleep inventory MA version), and portable physiological signal recorder. Subjects completed the PSQI and OSA-MA before treatment, after two weeks, and after the cooling-up one week. Results The result of this study provided evidence that improvement due to this supplement was observed for the sleep quality score. After two weeks treatment, sleep quality, daytime dysfunction, sleep disturbance, initiation and maintenance of sleep, sleepiness on rising, sleep length, and refreshing were improved. And these improvements did not remain after following one week. Conclusions Bovine alpha S1-casein tryptic hydrolysate and Hemerocallis flower extract were effective for sleep disorders. Arginin and Ornithine have the helpful effect for improvement of sleep quality.
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