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薬理と治療
Abstract
Objective The study aimed to verify that ingestion of a multiple dietary supplement containing gymnemic acid, mulberry leaf extract, green tea extract, chitosan, and kidney bean extract would reduce the postprandial blood glucose level of subjects. Methods A randomized, double︱blind, cross︱over study was conducted for 20 participants aged 30 to 59 years whose postprandial blood glucose levels increased more than 130 mg╱dL, ingested the multiple dietary supplement containing 9.4 mg of gymnemic acid, 200 mg of mulberry leaf extract, 200 mg of green tea extract, 100 mg of chitosan, and 4.8 mg of kidney bean extract or placebo with rice as a test meal. The blood glucose and insulin levels were measured before and 30, 60, 90, and 120 minutes after the intake of a test meal, and compared with the changes between placebo and the multiple dietary supplement. Results Intake of the multiple dietary supplement was significantly suppressed the delta AUC (area under the curve)values of postprandial blood glucose and insulin levels after ingestion of a test mea(l P<0.05). We also observed significant suppression of the elevation of postprandial blood glucose and insulin levels at 30 min after ingestion of a test meal by intake of the multiple dietary supplement(P<0.05)Conclusions These results suggest the multiple dietary supplement containing 9.4 mg of gymnemic acid, 200 mg of mulberry leaf extract, 200 mg of green tea extract, 100 mg of chitosan, and 4.8 mg of kidney been extract suppresses the elevation of postprandial glucose level.
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