薬理と治療

Abstract

Background In recent years, the number of patients with erectile dysfunction（ED）is increasing and becoming a serious problem every year. Korean mountain ginseng（Panax ginseng CA Meyer）are traditional herbal plants to improve sexual functions. In the present study, we investigated the effect of consuming tissue-cultured mountain ginseng（TCMG）for 12 weeks in improving male sexual function, as well as its safety. Methods In a double-blind, placebo-controlled trial, 45 healthy men with partial impotence （range: 35-70 years old）were randomized to oral TCMG（200 or 600 mg╱day）or-placebo administration for 12 weeks. The primary outcomes were International Index of Erectile Function（IIEF）and Aging Male Symptoms（AMS）scores. Results Forty-four subjects completed the study. TCMG compared to placebo could not be significantly effective against male sexual function, but the IIEF score after 12 weeks administration were significantly higher than before administration in the group treated with either 200 mg or 600 mg TCMG（P＜0.05）. Conclusion The present results suggest daily intake of TCMG between 200-600 mg might be beneficial for male sexual function.