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The Relationship between Plasma Levels of l—Arginine and NO after l—Citrulline Supplementation ―A Randomized, Double—blind, Placebo—controlled Trial―
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JPY
Abstract
Background L-Citrulline, a potent precursor of L-arginine, is known to be effective in enhancing nitric oxide(NO)production, which is a potent vasodilator and a critical modulator of vascular function. However, there is no direct evidence demonstrating the correlation between plasma L-arginine and NO levels following oral supplementation with L-citrulline. Methods In a double-blind, randomized, placebo-controlled cross-over protocol, 14 healthy females(27.8±6.0 years old)received L-citrulline(3.2 g╱day)or placebo for 5 days. Following supplementation, plasma levels of L-arginine, NOx, and changes in peripheral blood volume were determined sequentially. Results L-Citrulline supplementation significantly increased plasma L-arginine concentrations, as well as NOx levels. A significant correlation was found between the increase in plasma L-arginine and NOx levels following L-citrulline supplementation. Moreover, with L-citrulline intake, the recovery of the skin blood volume after cooling stress was markedly increased. No effects were observed with placebo. Conclusion These results showed for the first time that increased plasma L-arginine concentrations following oral L-citrulline raise the levels of plasma NOx correlatively, leading to enhancement of blood circulation in humans.
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