Full text loading...
薬理と治療
Abstract
Objective We examined a dose of sesame peptide(KM-20)on changes of blood pressure (BP)in volunteers with either high normal blood pressure or GradeⅠ hypertension. Methods 55 subjects including 34 males and 21 females, whose averaged year was 52.3, were divided 4 groups: Group A was a control group, subjects with BP at 145.5╱88.0; Group B was 250 mg╱day(low-dose), subjects with BP at 144.4╱87.6; Group C was 500 mg╱day(middle-dose), subjects with BP at 145.4╱87.4; Group D was 1000 mg╱day(high-dose), subjects with BP at 149.0╱89.3. Each group was given 4 capsules by orally once a day for 12 weeks. The BP was monitored every three weeks. Results A result of analysis of systolic blood pressure, the Group D showed significant improvement compared with that in the Group A at week 12(P<0.05). On diastolic pressure, the Group D showed significant improvement compared with that in the Group A at week 6(P<0.05)and the Group C improved significantly comparing with the Group A at week 10(P<0.05). A result of stratified analysis of systolic blood pressure with subjects of GradeⅠ Hypertension, Group D showed significant improvement compared with that in the Group A at week 12(P<0.05); on diastolic pressure, the Group D improved significantly comparing with the Group A at week 6(P<0.05). Discussion These results suggested that Sesame peptide(KM-20)would be useful for controlling BP in subjects with high normal blood pressure or GradeⅠ hypertension. Ile-Val-Tyr (IVY), an ingredient concerning to reduce blood pressure, is contained 300μg╱500 mg in sesame peptide(KM-20). Conclusion The optimum dose of sesame peptide(KM︱20)would be a dose either 500 or 1000 mg╱day from this report.
Data & Media loading...