薬理と治療

Abstract

Objectives A double-blind placebo controlled crossover clinical study was conducted on healthy adults volunteers to examine the effects of Terminalia bellirica extract on elevation of postprandial serum triglyceride. Methods The subjects were 34 healthy adult volunteers（mean age of 22.1±2.0 years）. The subjects were randomly divided to three groups and took a high fat meal（41.6 g fat）with test supplement containing 200 mg or 300 mg Terminalia bellirica extract （the 200 mg group, the 300 mg group）, or a placebo supplement（the control group）. Serum triglyceride was measured before and 2, 3, 4, and 6 hours after intake of the high fat meal. Results Compared to the control group, the 200 mg group and the 300 mg group had significantly lower serum triglyceride at 2 hours after the high fat meal and IAUC of postprandial serum triglyceride（each P＜0.05）.Conclusions These results suggested that the Terminalia bellirica extract had inhibitory effect on the elevation of postprandial serum triglyceride.