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コラーゲン加水分解物の褥瘡治癒促進効果―無作為割付けプラセボ対照化二重盲検試験―
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JPY
Abstract
Effect of a specific collagen hydrolysate(CH), which contains bioactive dipeptides, on healing of pressure ulcer was investigated in a randomized, placebo-controlled, double-blind trial. All subjects with Stage Ⅱ or Ⅲ pressure ulcer were treated with standard therapy, and we compared CH intake and placebo intake group. End point was a comparison between groups of levels of Pressure Ulcer Scale for Healing (PUSH)score, Pressure Score Status Tool(PSST) score and decubitus area score 16 weeks after ingestion. The levels of PUSH score and PSST score in the CH group decreased significantly compared to the placebo group(P<0.01). The level of decubitus area score in the CH group was also reduced significantly(P<0.05) than the level in the placebo group. Though there was no significant difference in blood albumin level of the subjects between the two groups, an intra-group significant difference in the level was observed in the CH group. This study demonstrated that the CH intake has a pressure ulcer healing effect added to the standard therapy.
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