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Effect of Partially Hydrolyzed Guar Gum on Postprandial Hyperglycemia―A Randomized Double—blind, Placebo—controlled Crossover—study―
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JPY
Abstract
Objectives The aim of this study was to evaluate the efficacy of partially hydrolyzed guar gum (PHGG)-containing supplement on the postprandial increase in blood glucose level in subjects with moderate postprandial hyperglycemia. Methods Volunteers(70 subjects)with their fasting blood glucose levels of 71-118 mg╱dL and postprandial blood glucose levels of 141-194 mg╱dL were enrolled in a randomized, double-blind, placebo︱controlled, crossover- study. Subjects ingested high-carbohydrate meal(115.6 g carbohydrate)together with either test supplement containing 4 g PHGG as 3 g dietary fiber or placebo supplement. Blood glucose and insulin levels were determined before and 30, 60, 90 and 120 minutes after the meal ingestion. Results The intake of PHGG supplement resulted in a significant decrease in postprandial blood glucose level compared to the level in placebo group. The area under the curve(AUC)for blood glucose level was 277.8±5.3 mg・h/dL(mean±SE)for PHGG group and 285.3 ±6.0 mg・h/dL for placebo group(P=0.043). Furthermore Cmax for blood glucose level was 168.1±3.0 mg/dL (mean±SE)for PHGG group and 174.1±3.3 mg/dL for placebo group(P=0.004)
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