薬理と治療

Abstract

Objectives The aim of this study was to evaluate the effect and safety of a dietary supplement （Kojun premium(R)）containing hyaluronic acid derived from chicken combs on knee pain, stiffness and discomfort. Methods We conducted a randomized, double-blind, placebo-controlled, parallel-group comparison study. The subjects, 80 adults whose Kellgren-Lawrence classification of osteoarthritis of the knee corresponded to 0-Ⅱ and who were not suffering from the disease, were randomly divided into two groups: the test product（chicken comb extract-containing supplement） group and the control product（placebo）group. Knee pain and discomfort were evaluated using a visual analogue scale（VAS）. The subjects were given each product for 12 weeks. Blood and urine samples were tested to evaluate the safety of the test product. Results Significant positive results demonstrating the effectiveness of the chicken comb extract-containing supplement appeared 4︱12 weeks after the intake as demonstrated by the VAS scores. The blood test results did not indicate any health hazard from the use of these supplements. Conclusion These results indicate that an intake of hyaluronic acid-containing supplements derived from chicken combs is safe and effective in managing knee pain, stiffness and discomfort.