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Long—term Intake of Glucosylceramide Extracted from Pineapple―Safety Evaluation in Healthy Adults―
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JPY
Abstract
Objective The objective of this study was to investigate the safety of long-term oral intake of glucosylceramide extracted from pineapple(PGC: 1.2 mg╱day)in healthy volunteers. Methods A double-blind randomized controlled study was conducted in 48 healthy volunteers (24 males, 24 females)to evaluate the safety of long-term PGC intake. Volunteers were randomly assigned to two groups and given either 1.2 mg╱day of PGC or placebo for 12 weeks. Body weight, body mass index (BMI), body fat percentage, blood pressure, heart rate, blood parameters, urine parameters, and subjective symptoms were recorded throughout the study. Results No clinically concerning changes in body weight, BMI, body fat percentage, blood pressure, heart rate, blood parameters, and urine parameters were found throughout the study. Conclusions The results indicated that PGC was safe for consumption in the healthy volunteers.
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