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Effect of a Combination of Hot Water Extract of Curcuma longa and Curcumin on Serum Liver Enzymes and Emotional States in Healthy Participants with Moderately High Body Mass Index―A Randomized, Double―blind, Placebo―controlled Clinical Trial―
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JPY
Abstract
Objectives We investigated the effect of a combination of hot water extract of Curcuma longa and curcumin on liver function and emotional states in healthy participants with moderately high body mass index(BMI). Methods A randomized, double︱blind, placebo︱controlled clinical trial was designed and conducted to evaluate the effects of a 12︱week treatment of the combination on serum liver enzyme levels and scores on the Profile of Mood States(POMS). Results Throughout the intervention period, aspartate aminotransferase(AST), alanine aminotransferase(ALT), and γ︱glutamyltransferase(γ︱GTP)levels did not differ between groups when all participants were included in the analysis. After excluding participants whose BMI changed substantially during the study period, decreases in AST levels were significantly greater and those in ALT levels tended to be greater in the combination group than in the placebo group for participants whose serum liver enzyme levels were in the normal range(i. e., AST or ALT<51 U╱L). Compared with the placebo group, the combination group showed a significantly greater improvement in all POMS subscale scores, except for Vigor scores. Conclusions The combination may be useful for maintaining liver health in people with borderline hepatitis and improving negative emotional states.
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