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薬理と治療
Abstract
Objectives A single blind test was performed to verify the safety of Extract Rose Drink(hereinafter referred to as ERD)and its efficacy in improving menopausal symptoms and relieving fatigue, when it is taken by drinking in the morning and evening for 60 days. Methods Seventeen Japanese women(35-55 years old)were instructed to drink one bottle of ERD in every morning and evening for 60 days. A questionnaire survey for menopause symptoms, GHQ-30 survey, keratin observation, skin moisture measurement, urine analysis, hematologic test and special hormone test(ACTH, LH, FSH, cortisol, serotonin, estradiol)were performed on Day 0(the first day of the drinking period), Day 30 and Day 60. Results In the questionnaire survey, 3 of 17 test-subjects showed subjective comprehensive improvement, and 12 of the remaining 14 showed no change. In GHQ-30 survey, 9 test-subjects who were judged to be“mentally unhealthy”on Day 0 were judged to be“mentally healthy”on Day 60. Although some differences were observed in subjective symptoms among the test-subjects, GHQ-30 survey revealed the improvement more objectively. Thus drinking ERD was assessed to have a tendency to improve subjective menopausal symptoms. As for keratinization, the state was improved in 16 of 17 test-subjects mostly depending on the number of times of drinking. The skin moisture increased in all test-subjects. Recovery of disordered skin barrier function is known to be inhibited by chronic stress. Therefore, state of the skin is considered to have been improved as a result of reduced chronic stress owing to drinking ERD. Conclusions The hematologic data and skin observations suggested that the chronic stress was reduced by intake of ERD. Further, the questionnaire surveys showed improved depressive symptoms. Based on these results, ERD is considered effective in improving depressive state and recovering fatigue although the degree varies with each personʼs constitution. Furthermore, no changes were noted in blood pressure, heart rate, urinalysis, or hematologic data, showing that ERD is a product having high safety.
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