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薬理と治療
Abstract
Objectives To investigate the dermatological effects of an Alpinia zerumbet leaves extract (ALE)on the skin of Japanese females. Methods A randomized, placebo-controlled, double-blind, parallel-group comparative study was conducted on 20 healthy females who provided informed consent. Subjects took either a beverage containing ALE or a placebo beverage once daily for eight consecutive weeks, and skin moisture content, transepidermal water loss, and skin elasticity were determined, in addition to skin texture replica analysis. Results A non-significant increase in skin moisture content was observed in the placebo group, while a significant increase in skin moisture content and a significant decrease in transepidermal water loss were observed in the ALE group. A significant increase in skin elasticity was also observed in the ALE group, whereas the skin replica analysis showed significant increases in the number of skin textures in both groups. No clinically relevant adverse events were observed throughout the study. Conclusion These findings suggested that the ALE may prevent skin dryness, moisturize the skin, and enhance skin elasticity. It was also suggested that the ALE is safe for consumption as a useful functional food.
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