薬理と治療

Abstract

Objectives In this study, we evaluated the effect of the food containing matured hop extract （MHE）, which contains matured hop bitter acids（MHBA）, on the body fat reduction. Methods A randomized, double-blind, placebo-controlled parallel group study was conducted on healthy subjects aged 20 to 65 years with a body mass index（BMI）of 25 to below 30 kg╱m2. One hundred and thirty-two volunteers were randomly divided into three groups and daily ingested 350 mL of the beverage that contained 215 mg MHE（35 mg MHBA）, 72 mg MHE（11.7 mg MHBA）, or no MHE for 12 weeks. As primary endpoints, total fat area, subcutaneous fat area, and visceral fat area were measured 0, 8, and 12 weeks after ingestion start and body fat percentage was measured 0, 4, 8, and 12 weeks after ingestion start. As secondary endpoints, body weight, body mass index, waist circumference, and hip circumference were measured 0, 4, 8, and 12 weeks after ingestion start. Results Visceral fat area significantly reduced in the MHE with 35 mg MHBA group compared to the placebo group. In the subjects which have less than 100cm2 visceral fat area, a significant reduction was observed in the visceral fat area in the MHE with 35 mg MHBA group compared to the placebo group. Conclusion These results indicated that the food containing MHE with 35 mg MHBA had an effect on the visceral fat reduction.