薬理と治療

Abstract

Objective L-Cystine is the oxidized dimer of cysteine in keratin from hair and nail. There are few data of the oral administration of L-Cystine to affect the quality of hair. In this study, we evaluated the oral administration of L-Cystine to increase the hair protein in low protein diet mice. Methods 6-weeks-old C3H╱HeJYokSlc male mice were divided into three groups as follows; Standard diet, Low protein diet, Low protein with L-Cystine diet. After five weeks to orally administration of test diet, hair was collected from back skin on mice. Hair protein was extracted and determined the amount of matrix and microfibril protein. The amount of matrix and microfibril protein from hair was determined with the band intensity of its SDS-PAGE. Results The amount of matrix and microfibril protein of low protein diet mice hair was lower than that of the standard diet mice hair. The protein content of low protein with L-Cystine diet mice hair was significantly increased that of low protein diet mice hair. Conclusions Oral administration of L-Cystine increased the hair protein in low protein diet mice. It is considered that the oral administration of L-Cystine increased the amount of hair protein.