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Hypotriglyceridemic Effect of Kale ―A Randomized, Double—blind, Parallel—group,Placebo—controlled Study―
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JPY
Abstract
Background Kale has health-promoting potentials. Our preliminary open-label study suggested that the intake of kale lowers serum triglyceride(TG)level in subjects with baseline serum TG levels of 150-199 mg╱dL. Objective The aim of this study was to confirm hypotriglyceridemic effect of kale in a randomized, double-blind, parallel-group, placebo-controlled study. Methods/study design We enrolled 78 volunteers whose fasting serum TG levels ranged from 120-199 mg╱dL. Subjects were randomly allocated to 3 groups; placebo(group P), low-dose(7g daily)kale (group L), and high-dose(14 g daily)kale(group H). The period of intake was 12 weeks. Two subjects(1each in group P and H)dropped out, and 76 subjects completed the study. After excluding 5 subjects(2 in group P; 3 in group H)who met the exclusion criteria for efficacy analysis, data obtained with 71 subjects were analyzed for efficacy. Results There was a marginal decrease in serum TG level in group H at the 8th week in the analysis of the whole subject population. In subjects with baseline TG levels of 150-199 mg╱dL, significantly lower TG levels (P<0.01)were observed in both group L and group H (150.8±35.1 and 139.3 ±55.9 mg╱dL, respectively)compared to the level in group P(215.3 ±47.9 mg╱dL)at the 8th week. No serious adverse event was observed during this study. Conclusion Our results suggest that daily intake of 7-14 g of kale benefits persons whose serum TG level is slightly higher than the normal range.
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