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薬理と治療
Abstract
Objectives We developed resistant glucan(RG), a form of purified water-soluble dietary fiber, through the activated carbon-catalyzed poly-condensation of glucose syrup followed by the removal of digestible saccharides. The beneficial physiological functions of RG as a dietary fiber, regarding the postprandial elevation of plasma glucose levels in human subjects, are not yet known. In the present study, we aimed to determine the inhibitory effects of RG on the absorption of sugars in the small intestine of rats, and on its postprandial plasma glucose level in human subjects with mainly borderline diabetes. Methods 1)The inhibitory effect of RG on the absorption of sugars in the small intestine was assessed by measuring the perfusion of glucose, sucrose and maltose in 8-week old male Sprague Dawley rats. 2)The randomized, double-blind, cross-over testing using 62 human subjects examined the inhibitory effects of RG on elevating the postprandial plasma glucose level. The plasma glucose and insulin levels were measured after ingesting 5 g of RG or a placebo(maltodextrin)in the loading meals. Results 1)RG significantly inhibited the absorption of glucose produced by the degradation of maltose. 2)Compared with the placebo, RG significantly inhibited the elevation of plasma glucose levels 60 and 90 min after intake, and lowered the plasma glucose area under the curve. Conclusions These results indicate that RG is a soluble dietary fiber which inhibits the elevation of postprandial plasma glucose levels in humans.
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