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薬理と治療
Abstract
Objectives Previous study has suggested that resistant maltodextrin(FS-2) suppresses postprandial blood triglyceride elevation and its mechanism of action due to an inhibition of lipid absorption. Hydrogenated resistant maltodextrin(FS-2H)has been developed by reduction of FS-2. Therefore, FS-2H may have some effects similar to FS-2. In this study, we evaluated whether FS-2H increases lipid excretion into feces through impaired micelle stabilization. Methods For fecal excretion of lipid, Sprague-Dawley rats were fed the high fat diet containing 2.5% and 5% FS-2H or FS-2 for 2 weeks. Feces were collected during the last 2 days and fecal lipids were extracted. Fecal triglyceride and total-cholesterol were measured. To see effects of FS-2H and FS-2 on micelle formation, micelle was prepared with fatty acid and bile acid. The micelle solution was left at 37℃ for 0, 60, 120, and 180 min in the presence or absence of fibers. Absorbance at 500 nm and average particle diameter of the micelle emulsion were measured. For lipase activity, lipid emulsion containing lipase was mixed with FS-2H or FS-2. Free fatty acid which was released from the lipid emulsion was measured. Results Fecal lipid excretion was significantly higher in FS-2H fed rats compared to those fed FS-2. Both FS-2H and FS-2 suppressed the reduction of absorbance at 500 nm and average particle diameter of lipid emulsion. No inhibition was found in lipase activity. Conclusions FS-2H showed enhanced fecal lipid excretion partly through the micelle stability, indicating that like FS-2 may be beneficial to regulate lipid absorption.
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