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オキナワモズク由来フコイダンを配合した飲料による便秘傾向者における便秘改善効果の検証―プラセボ対照ランダム化二重盲検クロスオーバー比較試験―
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JPY
Abstract
The aim of this study was to elucidate beneficial effect of Cladosiphon okamuranus fucoidan drink on healthy subjects with mild constipation. Volunteers(n=66; 17 male, 49 female; 44.5±8.6 years[mean±SD])were randomly divided into two groups and given 500 mg of fucoidan containing drink or placebo daily for 2 weeks in a double-blind crossover study. Each subject ingested 1 bottle of fucoidan per day for 2 weeks during the test period and 1 bottle of placebo caramel-water per day for 2 weeks during the placebo period. The result of this study showed that the ingestion of fucoidan increased significantly the defecation number of day and stool frequency(P<0.05)during ingesting period compared with those of placebo. The findings indicate that Cladosiphon okamuranus fucoidan containing drink increases in the number of days with defecation, stool frequency and improves mild constipation.
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