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Safety Evaluation of Alpha Linolenic Acid—enriched Diacylglycerol Consumption at Five Times the Effective Dose Against Visceral Obesity in Healthy Subjects―A Randomized, Double—blind Controlled,Parallel—group Designed Trial―
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JPY
Abstract
Objectives This study was performed to evaluate the safety of excessive consumption of alpha linolenic acid-enriched diacylglycerol(ALA-DAG). Methods A randomized, double-blind controlled, parallel-group trial was performed in 40 healthy subjects. The subjects were randomly allocated to either the control triacylglycerol (TAG)or ALA-DAG consumption groups. Daily consumption was set at 12.5 g╱d, which is five times the effective dose against visceral obesity. Safety parameters were assessed at the 0, 2, and 4 wk time-points. Results All subjects(n=20╱group)completed the study, and were included in the intention-to-treat samples. No adverse events associated with consumption of ALA-DAG occurred, based on blood biochemistry, hematology, or urinary analyses of the intention-to-treat samples. Conclusions The results suggest that excessive consumption of dietary ALA-DAG is safe in healthy subjects.
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