薬理と治療

Abstract

Objectives The aim of the present study was to investigate an effect of rare sugar syrup（RSS） on sucrose absorption in humans. Method Firstly, effect of RSS on α-glucosidase was assessed by measuring sucrase and maltase activities in the small intestine of rat. Secondly, effect of RSS with sucrose on blood glucose and insulin was evaluated by a series of two single blind, randomized, placebo-controlled crossover trials in humans. In 50 g tolerance test, 10 normal humans ingested one of 4 treatments with different ratios of RSS and sucrose, 0：10（control）, 3：7, 5：5 and 7：3, containing 50 g carbohydrate of each（dry solid base; dsb）in the fasting state. In 10 g tolerance test, 12 normal humans ingested 10 g（dsb）of mixtures at the ratio of 5：5 or 10 g sucrose as control in the fasting state. Blood was collected over 120 min after ingestion to check the blood glucose and insulin levels. Result Both sucrase and maltase activities were inhibited by RSS, and the inhibitory effect was stronger on sucrase. In 50 g tolerance test in humans, the ratio of 7：3 showed significant reductions in incremental areas under the curve（ΔAUC）of blood glucose and insulin, and the ratio of 3：7 showed significant reduction in insulin ΔAUC. Both 10 g and 50 g trials showed significant reductions in ΔAUC of blood glucose and insulin at the ratio of 5：5. Conclusion These results suggest that RSS has attenuating effect on blood glucose and insulin responses by inhibiting sucrase activity when ingested with sucrose.