Full text loading...
薬理と治療
Abstract
Objectives The objective of this study was to investigate the effect of a dietary supplement containing Yeast SM-10 on joint functions of individuals with knee joint pain. Methods A randomized double-blind placebo-controlled clinical study was conducted in 57 subjects with knee joint pain but without the diagnosis of osteoarthritis. They were randomly assigned to two groups and administered with either a test supplement containing 600 mg Yeast SM-10(Yeast SM-10 group)or a placebo(placebo group)per day for 12 weeks, and joint functions were evaluated with the diagnostic tools for locomotive syndrome(the 25-question geriatric locomotive function scale, standing test and two-step test)as well as JOA score. Results The results indicated that the subscales for the diagnostic tools for locomotive syndrome and JOA score were not significantly different between the placebo(n=29)and Yeast SM-10(n=28)groups during the intervention, when all the subjects containing those with mild hip joint pain and low back pain were analyzed. Then, the subjects without or with weak hip joint pain and low back pain(VAS scales of JHEQ and JLEQ<10 mm)were further analyzed. Notably, the two-step test was significantly improved in the Yeast SM -10 group(n=15)compared with the placebo group(n=8)at 12 weeks during the intervention. Similarly, the subscales of JOA score(pain on walking, pain on ascending or descending stairs and total)were improved in the Yeast SM-10 group compared with the placebo group at 12 weeks during the intervention. Conclusions These observations suggest that the daily administration of a test supplement containing 600 mg Yeast SM-10 is effective for improving walking ability of healthy subjects with joint pain.
Data & Media loading...