薬理と治療

Abstract

Background Several clinical trials have investigated the impact of coffee-derived mannooligosaccharides on the intestinal condition in various kinds of food products, but no systematic review was conducted. Objective The objective was to perform a systematic review with meta-analysis of randomized, placebo controlled trials of coffee-derived mannooligosaccharides to better understand its impact on intestinal condition in the healthy adults or adults with a tendency of constipation. Design A systematic literature search of scientific databases and register databases for clinical trials╱systematic review was conducted. The main outcome measures were defecation days╱week, defecation frequency╱week, fecal Bifidobacterium counts and the occupancy rate of Bifidobacterium in the total fecal microbiota. A random-effects model was used to calculate the standardized mean difference and 95％ CI as the difference between the mean for the treatment and placebo groups. Standard methods for assessing statistical heterogeneity and bias risk were used. The protocol for this study was registered to UMIN-CTR（No. 000025016）. Results Six studies met the inclusion criteria. The use of coffee-derived mannooligosaccharides improved the defecation days╱week［standardized mean difference（SMD）：0.62；95％ CI：0.37, 0.88］, defecation frequency╱week［SMD：0.65；95％ CI：0.40, 0.91］and increased the fecal Bifidobacterium counts［SMD：1.26；95％ CI：0.73, 1.79］and occupancy［. SMD：2.05；95％ CI：1.50, 2.60］ No heterogeneity was observed in the meta-analysis. Bias risk for body of evidence was rated as medium. Conclusion Coffee-derived mannooligosaccharides appears to beneficially affect intestinal condition in the healthy adults and adults with a tendency of constipation.