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薬理と治療
- Authors: Tadao Enomoto1, et al.
Abstract
Background In recent years, the prevalence rates of allergic diseases have been increasing. The predominant symptoms of allergic rhinitis are sneezing, nasal discharge, and nasal obstruction. Objective The effect of daily intake of kale containing food for 12 weeks was evaluated in men and women with nasal and ocular symptoms due to mite or house dust allergy. Methods/study design A randomized double-blind placebo-controlled parallel group comparison study was conducted in 120 Japanese adults. Subjects ingested one of the following powdered foods: high-dose kale containing food(H group), low-dose kale containing food (L group), and placebo food without kale(P group). The primary endpoint was change in QOL questionnaire scores from baseline(before study treatment). As secondary endpoints, scores for nasal and ocular symptoms were determined from symptom diaries, and some immune functions were measured. Results There were no significant improvements in QOL score between the H group and P group or between the L group and P group. According to the analysis of subjects with a low baseline salivary sIgA secretion rates, salivary sIgA secretion rates were increased in the H group and L group compared with those in the P group. In addition, the salivary sIgA secretion rate increased from baseline in all three groups. Among the QOL questionnaire scores, “the daily living score”showed greater improvement in the H group than the P group (significant at Week 4), and decreased in the L group. Symptom diary“nasal discharge”score showed greater improvement in the H group than the P group (significant at Week 8), and decreased in the L group. During this study, no safety problems related to intake of kale containing food were observed. Conclusion These findings suggest that daily intake of kale containing food for 12 weeks may activate immune function and may improve nasal and ocular symptoms in subjects with low salivary sIgA secretion rates.
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