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薬理と治療
Abstract
Objective The effect of ingesting a supplement containing Chlorella pyrenoidosa on defecation was evaluated. Methods We conducted a randomized, placebo-controlled, double-blind, cross-over study for forty healthy adult women who have mild constipation tendencies with 3 to 5 defecation frequency per week. Subjects consumed either fifteen tablets containing Chlorella pyrenoidosa as test food, or fifteen tablets containing maltodextrin instead of Chlorella pyrenoidosa as placebo food twice a day(thirty tablets in a day)for four consecutive weeks. Defecation frequency, fecal amount, fecal characteristics, and abdominal symptoms were recorded by the subjects themselves throughout the duration of the experiment. Result During both period of the test food or the placebo food consuming, the defecation frequency significantly increased compared to those in the baseline period. The defecation frequency in the test food group was significantly increased compared with the placebo food group after three weeks. In addition, no clinical concerns such as changes in body weight, BMI, vital signs were noted during the ingestion period. No adverse events attributed to the test food or the placebo food were found in the study. Conclusion These results suggested that daily ingestion of the supplement containing Chlorella pyrenoidosa improved defecation conditions.
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