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Effect of Resistant Glucan on Bowel Movements in Healthy Subjects―A Randomized, Double‒blind, Placebo‒controlled, Parallel‒group Trial―
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JPY
Abstract
We recently developed a new water-soluble dietary fiber, resistant glucan(RG). RG was obtained by heating glucose syrup with activated carbon, followed by enzymatic treatment and fractionation of dietary fiber. We studied RG utilization by intestinal bacteria, and the effect of RG on bowel movement. We found that RG is utilized by major species of human intestinal microflora, such as Bifidobacterium sp. and Bacteroides sp. Because RG was expected to improve intestinal function, 5 g╱day RG(dry solid basis)was administrated for 2 weeks to 70 subjects who tended to be constipated. The study was designed as a randomized, double︱blinded, and placebo-controlled parallel-group trial. Each subject received RG or placebo(maltodextrin)for 2 weeks. RG ingestion significantly increased defecation frequency(P<0.05)during the trial. The number of defecation days showed a tendency to increase(P<0.10)during RG ingestion. Therefore, our findings indicate that RG may promote the improvement of bowel movement.
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