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薬理と治療
Abstract
Objective The aim of this study was to investigate the ability of beeswax to act as blood absorption enhancer of DHA and EPA. Methods Animal study;Six rats and six mice were divided into two groups: the 0.95 mL╱kg fish oil plus 0.05 mL╱kg olive oil as control group(n=3)and 0.95 mL╱kg fish oil plus 0.05 mL╱kg beeswax as beeswax group(n=3). The feed was single dose administered into the stomach using a gastric tube. To measure fatty acids, lymph and blood were collected just after administration and several time points up to 6 hours after administration. Clinical study;Eleven healthy men aged 23-41 years ingested 5 beeswax capsules(containing 80 mg DHA, 20 mg EPA and 5 mg beeswax ╱capsule) or 5 control capsules(containing 80 mg DHA and 20 mg EPA╱capsule). For all participants the capsules intake has been separated by a washout period of seven days. In order to measure DHA and EPA plasma concentration, blood was collected before intake and several time points up to 24 hours after intake. Results In animal study, DHA and EPA plasma ratio in total plasma fatty acids was significantly increased between 3 and 6 hours from administration in beeswax group compared with control group(P<0.05). In clinical study, DHA and DHA plus EPA incremental concentrations were significantly higher at 2 and 4 hours after the intake of beeswax containing capsules than control capsules(P<0.05). Conclusions Based on the results of the present study it can be considered that the intake of beeswax containing capsules might induce an enhanced rate and extent of blood absorption of DHA and DHA plus EPA which could lead to broader benefits in other health outcomes.
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