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アンペロプシン含有藤茶エキスおよびキトサン含有食品の長期摂取時の血清尿酸値への影響と安全性の評価―無作為化二重盲検プラセボ対照並行群間比較試験―
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JPY
Abstract
Objective This study aimed to verify that the safety and effect on serum uric acid level of a dietary supplement containing vine tea extract and chitosan. Methods A randomized, double-blind, placebo-controlled, parallel-group comparison study was conducted for 78 male subjects aged 22 to 64 years whose serum uric acid levels were between 6.0 mg╱dL and 7.0 mg╱dL. The subjects consumed either a dietary supplement containing 500 mg of vine tea extract which contained 150 mg of ampelopsin and 100 mg of chitosan, or placebo for 12 consecutive weeks. The primary endpoint was the change from baseline of serum uric acid levels and the secondary endpoints were urinary uric acid excretion, uric acid clearance, creatinine clearance, and uric acid clearance -creatinine clearance rate. Results The change in serum uric acid level from baseline by the intake of the test supplement was significantly lower than that of placebo. On the other hand, in the secondary outcomes, no improvement effect by ingestion of the test food was observed. There was no safety problem of the test supplement under this test condition. Conclusions These results suggested intake of a dietary supplement containing 500 mg of vine tea extract and 100 mg of chitosan reduces serum uric acid level.
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