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Effect of Intake of Jelly Compounded with 3,5—dihydroxy—4—methoxybenzyl Alcohol(DHMBA)—containing Supernatant Extracted from Soft Tissue of the Pacific Oyster (Crassostrea gigas)on Fatigue in Healthy Middle—aged Men and Women ―Randomized, Double—blind, Placebo—controlled, Comparative Study―
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JPY
Abstract
Objective The objective of this study was to investigate the effect of intake of jelly compounded with 3,5-dihydroxy-4-methoxybenzy- alcohol(DHMBA)-containing supernatant extracted from soft tissue of Crassostrea gigas on fatigue in healthy adult working men and women. Methods Healthy adult working men and women(84 study subjects)were enrolled in a randomized, double-blind, placebo-controlled, comparative study. The study subjects took 4 packets of jelly compounded with DHMBA-containing supernatant extracted from soft tissue of C. gigas or placebo jelly every day for 4 weeks. The fatigue state was evaluated using the Profile of Mood States Short form(POMS-S)and OSA sleep inventory MA version(OSA-MA). Results In a stratified analysis in subjects aged 41 years or older, changes in the scores of POMS-S before intake of the study food for“depression”at weeks 2 and 4 were -17.3 ± 2.6 and -21.6 ± 2.0, respectively and for “fatigue”-13.5 ± 1.6 and -18.2 ± 2.2, respectively in the group receiving the jelly compounded with DHMBA-containing supernatant extracted from soft tissue of C. gigas, whereas the changes were -9.9 ± 2.0 and -15.3 ± 1.9 for “depression” and -8.5 ± 1.8 and -10.6 ± 1.8 for “fatigue” in the placebo group, showing a significant improvement in the Watanabe Oyster DHMBA Jelly group than in the placebo group. The change in the score of OSA-MA for the first factor(sleepiness on waking)at week 4 in the group receiving jelly compounded with DHMBA-containing supernatant extracted from soft tissue of C. gigas was 8.79 ± 1.75, showing a significant improvement in the Watanabe Oyster DHMBA Jelly group compared to the placebo group(4.44 ± 0.99). There were no adverse events associated with the intake of the jelly compounded with DHMBA-containing supernatant extracted from soft tissue of C. gigas. Conclusion The intake of jelly compounded with DHMBA-containing supernatant extracted from soft tissue of C. gigas is effective in reducing the fatigue experienced in the daily lives of healthy middle-aged men and women.
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