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酵素分解蜂の子食品の耳鳴り症状に対する改善効果―無作為化並行群間単盲検比較試験―
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JPY
Abstract
Objectives The aim of this study was to investigate the lowest effective dose of enzymolyzed honeybee larvae powder(EHB)on tinnitus symptoms. Methods 66 subjects with mild self-perceived tinnitus handicap participated have been recruited in this study. The subjects were allocated to ora- treatment with either 180 mg or 360 mg or 540 mg or 720 mg of EHB or 720 mg of EHB combined with γ-aminobutyric acid (GABA group), Riboflavin and Cyanocobalamin or placebo daily for 12 weeks. The level of tinnitus symptoms has been evaluated at before treatment, 1 week, 2 week, 3 week, 4 week, 8 week, and 12 week after treatment, using a visual analog scale(VAS). Results 65 subjects have completed the trial. There are significant improvements related with VAS score of tinnitus in 360 mg, 720 mg and GABA group compared with placebo group at any point in time. However, no significant differences were found in 180 mg and 540 mg group. Conclusion Our results suggest that EHB supplementation with doses of 720 mg╱day is likely to be effective for relieving of tinnitus symptoms.
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