Full text loading...
薬理と治療
Abstract
Objectives In the study, we evaluate the improvement effect of supplemented L-citrulline on sensitivity of cold in females. Methods We conducted a randomized, placebo-controlled, double-blind, crossover study for 25 healthy adult females who complain of feel coldness. Subjects were consumed either tablets containing 800 mg L-citrulline as test food, or containing maltose instead of L-citrulline as placebo food once a day for two consecutive weeks. The subjects visited the clinic on the 14th day consuming the test or placebo food. In each visit, subjects participated cold exposure test measured the skin surface temperature of specific points of left hand and a bodily sensation by the Visual Analogue Scale (VAS)for feeling of coldness at before exposure, just after exposure, 10, 20, 30, and 60 min after exposure. Results In the result of cold exposure test, the temperature of back of the hand and wrist in test food group was significantly higher than placebo food group at 10 min after exposure. In the temperature of wrist at 20 min after exposure, test food group was shown significantly higher than placebo food group. The sensation of cold in the hand in test food group was shown significantly low value compared with placebo food at 30 min after exposure. Conclusions These results suggest that a tablet containing L-citrulline would be useful for improving sensitivity of cold.
Data & Media loading...