No data available.
Please log in to see this content.
You have no subscription access to this content.
The full text of this article is not currently available.
健常な成人男女を対象としたクロセチンの長期摂取安全性試験―ランダム化二重盲検プラセボ対照並行群間比較試験―
Rent:
Rent this article for
JPY
Abstract
Objective Crocetin, a type of carotenoid, is a yellow pigment found in Gardenia fruits. The purpose of this study was to evaluate the safety of long-term intake of crocetin in healthy adult volunteers. Methods This study was a randomized, double-blind, placebo-controlled, parallel-group comparison trial. A total of 32 volunteers were randomly assigned to one of two treatment groups. The first group took a crocetin capsule(7.5 mg per capsule), and the second took a placebo capsule, once per day for 12 consecutive weeks. The safety of crocetin intake was evaluated by analyzing physical examination, blood biochemistry, hematology, and urine. Results The long-term intake of crocetin caused significant changes on safety parameters;however, the changes were sporadic. Small variations within the normal range were observed on blood biochemistry analyses and hematological tests, which were considered clinically insignificant and unrelated to the treatment. Therefore, no crocetin-related adverse changes were observed in the participants of this study. Conclusion The long-term intake of crocetin(7.5 mg╱day)was safe under the conditions of this study.
Full text loading...
/content/article/0386-3603/46050/801