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薬理と治療
Abstract
Objectives The aim of this study was to investigate the effect of a dietary supplement containing porcine skin collagen peptides on knee joint functions in subjects with pain and discomfort. Methods A randomized, double-blind, placebo -controlled parallel-group, comparison study was conducted in 30 healthy subjects (40-74 years old)with Kellegren-Lawrence grades of 0 orⅠ, without the diagnosis of osteoarthritis. They were randomly divided into two groups and administered with either the test product(125 mL drink containing 10 g collagen peptides derived from porcine skin)per day or the control product(placebo drink)for 12 weeks. The knee joint functions including pain and discomfort were evaluated using JKOM(Japanese Knee Osteoarthritis Measure)and the scores of locomo(locomotive syndrome)test. Results The scores of locomo test were not significantly changed. Interestingly, however, the JKOM Ⅳ criteria(general activities)was significantly improved at 12 week in the test product containing collagen peptides compared to the placebo group. Conclusions These result suggested that the daily supplementation of porcine skin collagen peptides is effective for improving QOL of the subjects with knee pain and discomfort.
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