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薬理と治療
Abstract
Objectives Recently, the incidence of lifestyle-related diseases, such as hypertension, dyslipidemia and diabetes, is increasing according to the National Health and Nutrition Survey Japan, 2016. Arterial stiffness, which is accelerated by complications of these diseases, is one of the highest risk factors for cardiovascular and cerebrovascular diseases. Vascular endothelial cells secrete many vasoactive factors and protect vascular function; therefore, impaired endothelial vascular function indicates the early stage of arterial stiffness. The current randomized, double-blind, placebo-controlled, crossover study was conducted to investigate the effects of black soybean seed coat extract on improving endothelial vascular function. Methods Twenty-four healthy volunteers were randomized to oral administration of 100 mg of black soybean seed coat extract(58 mg as black soybean polyphenols)or placebo for 4 weeks. We measured the % of forearm blood flow╱basal forearm blood flow(%FBF), whichreflects endothelial vascular function, using strain gauge plethysmography. Results The black soybean seed coat extract group had a significantly higher % FBF compared with the placebo group after 4-week administration, demonstrating that black soybean seed coat extract improved endothelial vascular function. In the safety evaluation, no adverse events were observed related to the test foods.Conclusions These results suggest that black soybean seed coat extract is a useful food material to improve and maintain endothelial vascular function in healthy people.
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