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薬理と治療
- Authors: Koji Okamoto1, et al.
Abstract
Objective The objective of this study is to examine how the ingestion of a supplement containing bilberry extract“, Kita-no-kuni kara todoita blueberry”(“KB”)contributes to eye conditions and functions. Methods A randomized, placebo-controlled, double-blind study was conducted to elucidate the effect of the supplement. In this study we measured the visual analog scale (VAS)as the primary outcome. We also evaluated the critical flicker fusion frequency(CFF)and accommodation ability such as near point distance(NPD)and diopter(D)as the secondary outcome. These were measured 3 times(pre- and post-reading pages aloud and VDT work, after the rest)on every visit. Moreover adverse events were collected by means of a written questionnaire during the study. Results From all of 76 applicants, 28 were eliminated due to not meeting inclusion criteria and 1 declined to participate. After 47 subjects were randomly assigned to an intervention group, 4 declined to participate, thus 43 made a start with ingestion. 3 subjects discontinued due to personal reasons, and the remaining 40 subjects completed the study. 1 was eliminated because of inadequacy of the VAS documentation, data obtained with 39 subjects(KB 21, Placebo 18)was used for the analysis of efficacy. After 12-weeks of ingestion, the intergroup analysis showed a significant difference in VAS of“Eye strain”for the previous week. In addition, a significant difference was depicted in CFF differences of measured values between two groups. No adverse events were observed during a 12-week ingestion period. Conclusion We found out that the ingestion of KB for 12 weeks resulted in recovery from eye fatigue.
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