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薬理と治療
Abstract
Objective The aim of this study was to elucidate the effect of supplementation of 10 billion Lactobacillus pentosus strain S-PT84(S-PT84)on the abdominal fat mass reduction and its safety in human. Methods We performed a randomized, double-blind, placebo-controlled trial. One hundred thirty Japanese subjects aged over 20 years old with a body mass index(BMI)of 25 to below 30 were randomly divided into two groups and were administered either S-PT84(1.0⊠1010 cells╱day)or matching placebo once a day for 12 weeks. Abdominal fat area was measured by computerized tomography before and after the 12 week supplementation in both groups. Results Total fat area(TFA)and subcutaneous fat area(SFA)in S-PT84 group were significantly decreased greater than those in placebo group. A significant reduction was not observed in visceral fat area (VFA)after 12 weeks in S-PT84 group compared with placebo group. In the subjects which have less than 100 cm2 VFA, significant reduction was observed in TFA and SFA in S-PT84 group compared to placebo group. No adverse effects were observed in both groups. Conclusions The present results indicate that the supplementation of 10 billion S-PT84 decreased abdominal fat in Japanese subjects.
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