薬理と治療

Abstract

Background Tea catechins have been showed to reduce visceral fat and body weight. This individual participant data（IPD）meta-analysis was to assess the overall effect of tea catechin supplementation（tea catechins rich beverage）on Japanese healthy adults. Design Systematic review and meta-analysis of individual participant data（IPD）from randomized, double-blind, placebo-controlled trials. Data sources Medline（PubMed）, JDream Ⅲ and University hospital Medical Information Network （UMIN）Clinical Trials Registry from inception to January 2018. Eligibility criteria for selecting studies Randomized, double blind, placebo controlled trials of ingestion of tea catechins（tea catechins rich beverage）for 12 or more weeks were eligible for inclusion if data of body fat or visceral fat were collect and if participants were Japanese adults. Results Seven eligible randomized controlled trials（total 1052 participants）were identified. IPD were obtained for 1049 participants. Tea catechins reduced abdominal visceral fat area （－8.83 cm2; 95％ confidence interval －11.14 to －6.52）, abdominal subcutaneous fat area （－11.45 cm2; 95％ confidence interval －14.34 to －8.55）, and abdominal total fat area （－20.66 cm2; 95％ confidence interval －24.71 to －16.61）. Adverse effects caused by tea catechins were not observed. Conclusions Tea catechins have body fat and visceral fat reducing effects in Japanese healthy adults.