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薬理と治療
Abstract
Background/Objective Coffee chlorogenic acid has been showed to reduce blood pressure. This individual participant data(IPD)meta-analysis was to assess the overall effect of coffee chlorogenic acid supplementation on gradeⅠ hypertension and high-normal blood pressure. Design Systematic review and meta-analysis of individual participant data(IPD)from randomized, double-blind, placebo-controlled trials. Data sources Medline(PubMed), JDreamⅢ and University hospital Medical Information Network Clinical Trials Registry(UMIN-CTR)from inception to May 2018. Eligibility criteria for selecting studies Randomized, double-blind, placebo-controlled trials of ingestion of coffee chlorogenic acid for 12 or more weeks were eligible for inclusion if data of blood pressure were collected. Results Three eligible randomized controlled trials(total 450 participants)were identified. IPD were obtained for 432 participants. Coffee chlorogenic acid reduced blood pressure in grade 1 hypertension and high-normal blood pressure participants(systolic blood pressure -7.3 mmHg, 95% confidence interval -8.3 to -6.3; diastolic blood pressure -4.2 mmHg, 95% confidence interval -5.2 to -3.2). In the subgroup analysis, chlorogenic acid reduced blood pressure(systolic blood pressure -8.6 mmHg, 95% confidence interval -10.3 to -6.8; diastolic blood pressure -4.8 mmHg, 95% confidence interval -6.3 to -3.3)in gradeⅠhypertension participants and reduced blood pressure(systolic blood pressure -6.7 mmHg, 95% confidence interval -7.8 to -5.6; diastolic blood pressure -4.3 mmHg, 95% confidence interval -5.6 to -2.9)in high-normal blood pressure participants. Adverse effects caused by coffee chlorogenic acid were not observed. Conclusions Coffee chlorogenic acid has a blood pressure lowering effect in gradeⅠ hypertension and high-normal blood pressure Japanese adults(. UMIN-CTR ID:UMIN000032524)
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