薬理と治療

Abstract

Objective We evaluated the effects of 12 weeks ingestion of dietary supplement containing rutin-rich Tartary buckwheat“Dattan Soba Seikatsu”on the blood pressure and blood flow in this randomized, double-blind, placebo-controlled, parallel-group study. Methods Fifty healthy Japanese people with the conditions of a）and╱or b）were divided into active test and placebo groups. a）SBP is≥130 mmHg and＜160 mmHg or DBP is≥85 mmHg and＜100 mmHg. b）Home SBP is≥125 mmHg and＜155 mmHg or home DBP is≥80 mmHg and＜95 mmHg. Subjects ingested active test dietary supplement（containing 4.8 mg rutin）or placebo dietary supplement（not containing rutin）daily for 12 weeks. Physical, and blood examinations and medical interviews were conducted at weeks 0, 4, 8, and 12. Results Blood pressure did not significantly differ between the groups. However, blood flow at rest significantly differed between groups at 12weeks. Moreover, in the subgroup with normal blood pressure and relatively severe chillness of hands and feet, blood flow at rest significantly differed between groups at 12weeks and chillness of hands and feet were improved at 12weeks relative to 0week in the active test group. There were no adverse events related to the intake of the test foods. No medical changes or safety concerns were observed with physical and blood examinations nor reported during medical interviews during the trial. Conclusion Dietary supplement containing rutin-rich Tartary buckwheat improved blood flow of the finger and chillness of hands and feet（. UMIN-CTR ID：000026254）