薬理と治療

Abstract

Objectives HYAKUBYAKUKOJI is a milk fermented by koji mold containing branched-chain amino acids（BCAA）. Herein we investigate the anti-fatigue effect associated with the ingestion of HYAKUBYAKUKOJI in healthy adults with the habit of exercising. Methods In a randomized, open-placebo-controlled crossover study, healthy subjects were assigned to 2 groups（preceding ingestion of HYAKUBYAKUKOJI or control food）. As an exercise tolerance test, subjects underwent total 4 hours of body workload using a bicycle ergometer. After every 1 hour of body workload, subjects took a break of 10 min and ingested the test food. We evaluated the physical performances of the subjects by 10-s high-power test, measured subjective fatigue by visual analogue scale and modified Borg scale, blood collection and urinalysis-related fatigue before and after body workload, after 4-h break, and the next day, and also performed blood amino acids analysis. Results Ingestion of HYAKUBYAKUKOJI showed improvement in physical performance and reduced subjective fatigue compared with the control food. Moreover, blood BCAA concentration was maintained at the post-body workload in HYAKUBYAKUKOJI ingestion group. Conclusions In this study, we concluded that ingestion of HYAKUBYAKUKOJI before exercise produces anti-fatigue effect on the acute phase fatigue for healthy adults who routinely exercise（. UMIN000024254）