薬理と治療

Abstract

A randomized, placebo-controlled, double-blind, parallel-group comparison study on 24 healthy subjects（11 males and 13 females, 38.1±8.7 years old）was conducted to evaluate the safety of excessive intake of tablets containing Lactobacillus acidophilus strain L-92（L-92）. Subjects were randomly divided into two groups. Each group ingested tablets containing either L-92 at 11 times of recommended daily intake or the placebo tablets, without L-92, for 4 consecutive weeks. No abnormal change was observed during the physical examination, blood analysis and urinalysis after 2 and 4 weeks of intake in the test groups. No adverse event attributed to the test tablets was found in this study. In conclusion, these results demonstrated that tablets containing L-92 were safe for consumption by healthy subjects with or without symptoms of mild perennial allergic rhinitis.