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Agaricus blazei Murrill 培養菌糸体由来グルコマンナン(ATOM)のヒト癌型K—ras 遺伝子発現誘導型肺腺癌マウスにおける抗癌効果
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JPY
Abstract
Objective We investigated the antitumor effect of glucomannan(ATOM: Antitumor Organic substance Mie)from the mycelium of liquid-cultured Agaricus blazei Murrill on oncogenic K-rasG12V mediated lung adenocarcinoma formation in mice. Methods We examined on the antitumor effect and immune-histopathological test by the oral or intraperitoneal, administration using oncogenic K-rasG12V driven lung adenocarcinoma genesis bearing mice. Results The tumor was demonstrated to be oncogenic K-rasG12V driven lung adenocarcinoma. ATOM was glucomannan with a main chain of β-1,2-linked D-mannopyranosyl residues and β-D- gulcopyranosyl-3-O-β-D-gulcopyranosyl residues as a side chain. In the group oral administration with ATOM 250 mg╱kg╱day a highly significant inhibition was observed as compared with the control group. However the intraperitoneal administration at dose of 250 mg╱kg showed a weak antitumor effect. Conclusions These findings suggest that oral administration of ATOM may have a tumor suppressive effect on lung adenocarcinoma formation in vivo.
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