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Safety Evaluation of Aloe vera Gel Powder Containing Aloe Sterols in a 90—day Feeding Study in Rats
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JPY
Abstract
We assessed the repeated-dose oral toxicity of Aloe vera gel powder(AVGP)in male and female Sprague-Dawley rats by dietary administration for 90 days. Concentrations of 0.188%, 0.750%, and 3.000% in the diet resulted in more than 100, 400, and 1000 mg╱kg╱day intakes of AVGP, respectively. Treatment with AVGP did not induce any signs of toxicity in examinations including clinical signs, body weight, food consumption, ophthalmoscopy, urinalysis, hematology, blood chemistry, organ weights, gross pathology, and histopathology. In conclusion, the no observed adverse effect level of AVGP in a 90-day dietary toxicity study was judged to be greater than 1800 mg╱kg╱day(more than 160-fold the human intake in the previously conducted efficacy tests)
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