薬理と治療

Abstract

Objectives The aims of this study were to investigate the effect of B240 on saliva secretion on the different target age and dosage form from previous study, and to obtain knowledge about the mechanisms of saliva secretion. In addition, it was aimed at examining the possibility of the biological defense function of the oral cavity by B240. Methods The study was a randomized, double-blind, placebo-controlled study with 60 male and female healthy adults between 40 and 65 years old. All the subjects consumed their test tablets at breakfast for 28 days. Saliva weight, mucin content, pH, buffer capacity and cortisol concentration were measured. Results The intake of the B240 tablets increased the saliva weight and mucin content. However, the pH, buffer capacity and cortisol concentration were unchanged. Conclusions These findings suggest that B240 contributes to the production of substances related to the oral cavity defense. These results suggest that B240 has a potential to maintain the health of the oral cavity.