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薬理と治療
Abstract
Objective Nattokinase is a thrombolytic enzyme contained in natto, which is reported that it acts on endothelial cells and enhances the production of t-PA that is used for treatment such as myocardial infarction. The purpose of this study is to evaluate the blood flow improving effect of nattokinase on peripheral blood vessels. Methods We conducted a randomized, placebo-controlled, double-blind, crossover study for fifteen healthy volunteers(7 males and 8 females, aged from 30 to 48 years). Subjects consumed either soft capsules that contain 2000 FU of nattokinase(NSK-SD:110 mg)as test food, or the soft capsules that contain dextrin instead of nattokinase as placebo, together with 100 mL of water. The peripheral blood flow of middle fingers of both hands, the back of the left hand, the back of the right hand and insteps of both feet were measured before and 40, 80, 120, 180 minutes after consumption of the test food. Result The consumption of nattokinase significantly improved the change in peripheral blood flow in the middle fingers of both hands compared to the placebo. The change in peripheral blood flow in the middle fingers 180 minutes after ingestion of the test food group was significantly higher than in the placebo group(P=0.026), and the rate of change from 0 minute in the test food group was significantly higher than that of the placebo group at 120,180 minutes after ingestion(P=0.036, P=0.016). No adverse events were observed in all subjects during the test period. Conclusion These results indicate that soft capsules containing nattokinase improve the peripheral blood flow of healthy adults.
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