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The Sleep Enhancement Supplement Japanese Sake Yeast Improves Skin Quality in Humans―A Randomized, Double—blind Placebo—controlled Clinical Trial―
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Abstract
Background Sleep quality is known to positively relate to skin condition. In our previous study, we demonstrated that Japanese sake yeast supplementation improves human sleep quality. However, it remains unclear whether sake yeast-mediated sleep improvement improves skin condition. Objectives In this study, we aimed to determine whether sake yeast supplementation as a sleep quality enhancer improves skin condition. Methods In a randomized double-blind placebo-controlled clinical study, healthy 20 subjects with low sleep quality were divided onto two equal groups. Ten subjects in each group ingested either tablets containing 500 mg of sake yeast powder or placebo for 5 weeks. The effects of sake yeast on skin condition were evaluated by cheek collagen intensity, trans-epidermal water loss(TEWL)and elasticity, hydration. Results The amount of change in collagen density(P=0.03), skin elasticity(P<0.01)and TEWL(P=0.04)was significantly improved in the sake yeast group compared with that in the placebo group. Conclusions Intake of Japanese sake yeast as sleep care supplement increases dermal collagen intensity and improve skin condition.
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