Full text loading...
薬理と治療
Abstract
Objective Favorable voiding function is essential for women, as well as for men, to keep good sleep quality and general quality of life(QOL). The objective of the present study was to examine the efficacy of quinic acid contained in cranberry juice(Q-CJ)on voiding frequency and associated impairment of sleep quality and general QOL, in healthy women bothering frequent voiding. Methods An open-label clinical study was conducted on 16 women aged between 26 and 69 years, receiving 100 mL of cranberry juice containing 980±20 mg Q-CJ per day for 12 weeks. Safety and compliance were monitored throughout the intervention. To evaluate the efficacy of Q-CJ consumption, Overactive Bladder Symptom Score (OABSS), the Japanese version of Nocturia Quality-of-Life Questionnaire(N-QOL), the Pittsburgh Sleep Quality Index-Japanese version(PSQI-J)and the voiding function-related questionnaire(AVFQ)were tested at baseline and at weeks 4,8, and 12 in all subjects. They were also required to keep urination dairy every day over the intervention period. Results There were statistically significant improvement in OABSS, PSQI-J and AVFQ at all or many evaluation timepoints during the intervention when compared with baseline data. Q-CJ was well-tolerated and safely taken by all subjects, except that a relationship with the intervention cannot be ruled out in one subject who experienced a mild diarrhea over the intervention period. Conclusion The results of the present study are the first finding that Q-CJ may significantly improve frequent daytime and likely improve nocturnal voiding, together with beneficial effects on impaired sleep quality and general QOL(. UMIN-CTR/UMIN000022829)
Data & Media loading...