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Inhibitory Action of a Composite Food Containing Salacinol, Resistant Maltodextrin, Epigallocatechin Gallate, Monoglucosyl Rutin and Phlorotannin on the Elevation of Postprandial Serum Triglyceride Level ―A Randomized, Double—blind, Placebo—controlled Crossover Trial―
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JPY
Abstract
Background Fasting hypertriglyceridemia can lead to cardiovascular and cerebrovascular diseases, and postprandial hypertriglyceridemia has also been shown to cause coronary artery disease. Objective We evaluated the effect of a composite food containing salacinol, resistant maltodextrin, epigallocatechin gallate, monoglucosyl rutin and phlorotannin on postprandial triglyceride level. Methods A randomized, double︱blind, placebo-controlled crossover trial was conducted in 40 subjects with slightly high fasting serum triglyceride levels. Serum triglyceride and remnant -like particle cholesterol levels were measured before ingestion and 2, 3, 4, and 6 h after intake of a high-fat meal that included 40 g of fat. We also evaluated the serum triglyceride and remnant-like particle cholesterol areas under the curve. Results Postprandial serum triglyceride levels were suppressed 2 and 6 h after ingestion of the composite test food, and the areas under the curve were smaller. Conclusion These findings indicate that the composite food suppresses the elevation of postprandial serum triglyceride and remnant-like particle cholesterol levels in healthy subjects.(UMIN ID:UMIN 000026135)
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